It turns out that Debra Danielson, the mother of Teen Mom's Farrah Abraham, was very wrong about the things her daughter is capable of doing. Not only has the 21-year-old actually made a sex tape -- an action she initially denied -- but now she's trying to make millions selling it.
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By Ransdell Pierson
(Reuters) - U.S. regulators have granted a "breakthrough therapy" designation to an experimental Pfizer Inc treatment for breast cancer, lifting the company's shares and putting a spotlight on its growing cancer-drug portfolio.
Analysts from JPMorgan and Leerink Swann forecast the oral medicine, called palbociclib, could generate annual sales of $5 billion or more if it is approved for use against breast cancer as well as other types of cancer.
Pfizer, whose stock rose 2.6 percent, said the U.S. Food and Drug Administration conferred the special status on palbociclib based on impressive results seen in mid-stage trials. The drug is now being tested in a larger Phase III study.
The FDA created the "breakthrough therapy" designation earlier this year for medicines deemed likely to demonstrate "substantial improvement" over existing drugs. It is intended to speed development and regulatory review of such medicines.
Leerink Swann analyst Seamus Fernandez said palbociclib could generate annual sales of $2.4 billion by 2020 if it is approved for breast cancer. He predicted the current study would show palbociclib slows tumor growth and prolongs life.
JPMorgan analyst Chris Schott called the FDA decision a "clear positive for Pfizer shares" and predicted palbociclib will be approved by 2016 or sooner thanks to acceleration under the "breakthrough" designation.
Palbociclib is being tested in combination with a standard drug, letrozole, in a Phase III trial of patients undergoing initial treatment for locally advanced or metastatic breast cancer.
Pfizer said interim data from the earlier mid-stage trials showed patients on the combined therapy went an average 26.1 months without a worsening of symptoms, compared with 7.5 months for patients taking only letrozole.
Palbociclib works by blocking two enzymes: cyclin dependent kinases (CDK) 4 and 6.
Pfizer, which has struggled in the past decade to come up with important new medicines, has won respect with recent approvals of three cancer drugs: Xalkori for lung cancer, Inlyta for kidney cancer and Bosulif for leukemia.
Pfizer shares were up 77 cents to $29.88 in early-afternoon trade, outpacing a 1.2 percent rise for the ARCA Pharmaceutical Index of large U.S. and European drugmakers.
(Reporting by Ransdell Pierson; editing by John Wallace)
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WASHINGTON (AP) ? The White House is celebrating the history and sound of Memphis soul music.
Legendary artist and younger acts, ranging from Sam Moore and Mavis Staples to Ben Harper and Justin Timberlake, were rehearsing at the White House on Tuesday to help President Barack Obama and Michelle Obama highlight that style of music at an evening concert.
Students from around the country participated in a workshop with some of the artists.
The event is the 10th installment in the "In Performance at the White House" series. It is scheduled for broadcast April 16 on PBS stations.
Starting in February 2009, the series has celebrated the music of Stevie Wonder, Paul McCartney, Burt Bacharach and Hal David, Hispanic music, music from the civil-rights era, Motown and the blues, Broadway and country music.
Source: http://news.yahoo.com/white-house-celebrates-sounds-memphis-soul-164730499.html
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Ronan, a California sea lion with a knack for keeping a beat, challenges theories about the nature of rhythmic ability.?
One of our resident sea lions, Ronan, is the first non-human mammal shown able to find and keep the beat with musical stimuli. This challenges earlier evidence from humans and parrots suggesting that complex vocal mimicry is a necessary precondition for flexible rhythmic entrainment.If you're like most people, the last time you threw a dance party you invited only humans, cockatoos, parrots, and parakeets.?
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Which makes perfect sense, because the only animals capable of keeping a beat, as far as anyone knew, were mimicking birds and (some) humans.
But new research suggests that for your next interspecies soir?e, you might need to fill a kiddie pool and stock your fridge with herring, because it turns out that sea lions may also show a sense of rhythm.?
Researchers at the Pinniped Cognition & Sensory Systems Laboratory at the University of California, Santa Cruz's Long Marine Laboratory, trained Ronan, a 4-year-old California sea lion, to bob her head in time with music. It is the first time a nonhuman mammal has been observed keeping a beat.
Before Ronan danced her way onto the scene, animal behaviorists were beginning to agree that keeping a beat ? "rhythmic entrainment" in science-speak ? was in some way a byproduct of neural adaptations that allow vocal mimicry. Inspired by popular YouTube videos of Snowball, a sulfur-crested cockatoo getting down to the Backstreet Boys' "Everybody" and Queen's "Another One Bites the Dust," researchers conducted an extensive search of the video database to find that every example of beat keeping, as far as they could tell, was done either by mimicking birds or humans. (It's mostly humans, actually. And most aren't very good.) ?
But Ronan changes all that. "The idea was that beat keeping is a fortuitous side effect of adaptations for vocal mimicry, which requires matching incoming auditory signals with outgoing vocal behavior," said lead researcher Peter Cook, in a university press release.
"It's understandable why that theory was attractive. But the fact is our sea lion has gotten really good at keeping the beat. Our finding represents a cautionary note for an idea that was really starting to take hold in the field of comparative psychology."
Now Ronan has a viral video of her own. Watch as she grooves to Earth, Wind & Fire's 1979 hit, "Boogie Wonderland," and then, later in the video, the Backstreet Boys' 1997 song, "Everybody." The researchers also trained Ronan to bob her head to Creedence Clearwater Revival's "Down on the Corner."?
Ronan, notes Mr. Cook in the press release, actually stays on the beat better than birds who have been trained to do so. And he suspects that brain structures for keeping a beat might be widespread throughout the animal kingdom.?
"Human musical ability may in fact have foundations that are shared with animals," Cook said. "People have assumed that animals lack these abilities. In some cases, people just hadn't looked."
Exactly what those brain structures are, however, is still anybody's guess. The paper says that Ronan's behavior is consistent with "some sort of neural oscillation mechanism with a preferred endogenous rate being driven by an external rhythm."?
If that's the case, and if these mechanisms are present in humans as well, then Cook and his team may have helped figure out what, in the most literal sense, makes us tick. ?
The research appears in the current issue of the American Psychological Association's Journal of Comparative Psychology. ?
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Sociology students study everything from pop culture to religion to food. Tossed in the mix are some pretty amazing classes that sociology students get credit for taking. Check out these top picks.
Like, totally, for sure! Given the influx of perfect men and posh women we see in the media, from The Hills to Katy Perry?s California Gurls, it?s no wonder we are curious about this West Coast wonder. This class takes on the ideals we have of Californian society and how it has evolved in most recent times.
Interested in all things Terminator? Take your sci-fi fantasies to the next level by studying the cultural practices associated with biomedical knowledge. Rumor has it that you?ll actually be screening one of the Terminators, too.
This class isn?t focused on the fundamentals of the Telephone Game we learned in elementary school. Here you?ll discover the ways that gossip perpetuate knowledge and cultural norms. Study the works of Kierkegaard and Freud to discover how gossip is related to every part of our lives.
At the birthplace of sociology, the University of Chicago held a one-day UChicago Conference that focused on all things Guido. Students discussed everything from GTL to the honor code of Seaside. This course exposed the cultural side of the Shore.
In love with Captain Jack Sparrow or the ideals of love from the Dread Pirate Roberts, this is the class for you. Parrots aside, this class focuses on the cultural history and relevance to why we are so fascinated by piracy.
Future Miss Americas, this will not give you the secrets to makeup, body tape or the perfect hair. However, you will learn about how the history of beauty pageants is interwoven in our culture. Expect to discuss the influences of Toddlers and Tiaras, and a trip to watch a real life beauty pageant is in the syllabus.
Take your love for environmental issues to the next level and enroll in a course about garbage. Learn about the life cycle of garbage and its effect on those living in the places where it is processed or dumped.
From her Little Monsters to her meat steak dresses, she?s certainly got our attention. A key player in the music biz, whether you like her or hate her, you have heard of Lady Gaga. This course explores why we are so interested in this singer and how this reflects on our society.
Over in Claremont, California, you can take a class focused on getting inked. No, this course is not a hands-on lesson in how to give a tattoo, but rather a sociological analysis of the culture of tattooed groups.
Curious to know how we manage in hostile environments, such as wars, famine or terrorism? Get signed up for this course to mull over questions about basic survival of humanity. Dig in deep with a focus on scientific literature and individualized experiences as they relate to unbearable life events.
A study of self as it relates to society as a whole, this course examines the forces that influence an individual?s development and behavior. The perfect course for college freshman, expect to learn a great deal about yourself in relation to the Bigger Picture.
Source: http://www.sociology.com/2013/04/11-cool-courses-sociology-students/
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You could cut up to half the fat from chocolate without sacrificing taste by infusing it with fruit juice, scientists say.
iStockphotoYou could cut up to half the fat from chocolate without sacrificing taste by infusing it with fruit juice, scientists say.
iStockphotoChocoholics, rejoice!
British scientists have developed a new fruit-juice-infused chocolate that they say has up to 50 percent less fat than the regular stuff. And it's tasty, too.
The scientists, led by University of Warwick's Stefan Bon, created the hybrid chocolate using a blender to generate microscopic droplets of fruit juice fine enough to blend into molten chocolate.
Bon and his team presented their research on Sunday at the annual meeting of the American Chemical Society in New Orleans.
According to Bon, these "micro-bubbles" of juice preserve that oh-so-satisfying velvety texture of chocolate, while also replacing much of the fat content. "This approach maintains the things that make chocolate 'chocolatey,' but with fruit juice instead of fat," he explains.
Sneaking fruit juice into chocolate may not change the "mouth feel" of the much-beloved treat, but Bon admits that it does subtly affect the taste.
"Obviously, the blend of fruit juice and chocolate gives it a twist," he writes in an email to The Salt. However, since the juice is spread out in the chocolate, Bon says that the taste isn't overwhelming and instead gives the chocolate "a hint of juice flavor."
So far, Bon's team has made chocolate infused with apple, orange and cranberry juice. And if you don't like fruit in your chocolate, don't worry. The scientists say that it's also possible to use other fluids to lower chocolate's fat content ? diet soda, vitamin C water, even alcohol (though that raises a whole new set of issues.)
For the boozy chocolate, the scientists had to develop a completely different infusion method. Instead of using a blender, they thickened up the chocolate using particles of agar gel, often used as a stabilizing agent in food.
"Using this alternative technique, we can not only introduce fruit juice and water, but also alcoholic beverages," writes Bon.
Although chocolate contains antioxidants, the potential health benefits of indulging in this treat can be negated by its high fat content if you overindulge. According to Bon, a two-ounce serving of dark chocolate can contain around 20 percent of your total daily recommended fat intake.
"We have established the chemistry that's a starting point for healthier chocolate," says Bon.
But don't run out to the candy store quite yet. Bon says that it's now up to the food industry to "take the next steps and use the technology to make tasty, lower-fat chocolate bars."
And while some chocolate purists may disagree, I, for one, see no problem sinking my teeth into a delicious bar of reduced-guilt chocolatey goodness.
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